This collection of John Webster Perit Huntington's papers consists mainly of correspondence and financial records created during Huntington's term as Superintendent of Indian Affairs in Oregon. Among these materials are sub-vouchers, bills, receipts, and other financial papers; a manuscript treaty with the "Snake or Shoshone Indians," dated December 10, 1868; a photostatic copy of an 1865 treaty with the confederated tribes and bands of Middle Oregon; affidavits relating to the death of Indian Agent William Logan in the wreck of the steamer Brother Jonathan, while he was carrying a large quantity of funds for the Indian Department; a document signed by Huntington concerning a land claim by a Klikitat man, Dick Johnson; and a letter from Jesse Applegate concerning Johnson's murder. Correspondents represented in the collection include Applegate, Benjamin Alvord, William Barnhart, B. F. Dowell, George S. Hinsdale, B. N. Huntington, William C. Johnson, William Kelly, John Kelsay, James W. Nesmith, Simeon G. Reed, and Benjamin Simpson, among others.

Other materials in the collection include Huntington's will; documents relating to the Unionist, his newspaper and printing business; and a scrapbook, titled "Life and Times of Eminent Oregon Politicians / Beautifully Illustrated / In Fragments," containing clippings of newspaper illustrations with handwritten satirical captions.